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. 2016 Apr 28;9(2):23. doi: 10.3390/ph9020023

Figure 3.

Figure 3

Effects of p38 inhibitors on the replicative capacity of WS and Normal primary fibroblasts. (a) Bar chart showing replicative capacity of fibroblasts from old and WS individuals. DMSO are controls, VX = 500 nM VX-745, UR = 1000 nM UR13756, SB = SB203580, B = BIRB 796; the numbers refer to nM concentrations, e.g., SB100 = SB203580 at 100 nM. (b) Data for the extended data set (Table S4) comparing NDFs from young (Ny) and old (No) individuals with WS. (c) Bar chart showing percentage increase in replicative capacity of fibroblasts from old and WS individuals expressed as mean ± SD (data from Table S3). (d) Mean replicative capacities (expressed as population doublings) of NDFs (all samples from Table S2) compared to WS fibroblasts ± inhibitor treatment. Statistical tests use the null hypothesis that the effects seen for inhibitors using WS fibroblasts are the same as that seen using NDFs, t-test. Significance levels only given for a subset of comparisons: ** highly significant (p < 0.01), * significant (p < 0.05).