Table 1.

Analgesic activity of compounds 1–8 in the AITC test in mice (2% w/w ointment).

Compound	Reaction Time (in s)	Compound	Reaction Time (in s)
Control	71.3 ± 1.8	4	25.3 ± 1.5
Benzocaine	48.0 ± 2.0	5	6.8 ± 1.2
1	2.7 ± 0.3	6	25.3 ± 3.8
2	20.3 ± 5.8	7	34.5 ± 2.2
3	22.8 ± 4.3	8	20.7 ± 2.8

All values are expressed as mean ± SEM; n = 6 mice; for all groups p < 0.01 compared with control group. One-way analysis of variance (ANOVA) followed by Tukey’s post hoc comparison.