Table 4.
Pharmacokinetic profiles of proton pump inhibitors for different phenotypes.
| Day I |
Day V |
||||||
|---|---|---|---|---|---|---|---|
| Group(n)a | Tmax(Hr)⁎ | Cmax(μg/ml)⁎ | AUC(μg/ml/Hr)⁎ | Tmax(Hr)⁎ | Cmax(μg/ml)⁎ | AUC(μg/ml/Hr)⁎ | |
| PPZ | PM(3) | 4.67 ± 1.15 | 5.94 ± 2.45 | 21.00 ± 10.13 | 1.67 ± 0.57 | 11.97 ± 1.80 | 43.48 ± 5.50 |
| NM(2) | 2.00 ± 0.00 | 4.57 ± 2.87 | 14.73 ± 5.83 | 2.75 ± 1.76 | 3.19 ± 3.86 | 10.59 ± 13.36 | |
| IM(2) | 4.00 ± 2.83 | 3.94 ± 0.44 | 17.65 ± 7.44 | 4.00 ± 0.00 | 9.57 ± 0.42 | 24.24 ± 14.14 | |
| RM(1) | 2.00 | 9.32 | 21.49 | 1.50 | 5.46 | 9.12 | |
| UM(1) | 2.00 | 4.31 | 12.39 | 4.00 | 4.14 | 7.18 | |
| p value⁎ | 0.27 | 0.45 | 0.72 | 0.29 | 0.13 | 0.17 | |
| EPZ | PM(5) | 3.60 ± 0.89 | 9.31 ± 4.86 | 27.49 ± 11.30 | 2.60 ± 1.34 | 3.61 ± 2.45 | 11.27 ± 7.30 |
| IM(8) | 7.25 ± 6.92 | 4.03 ± 2.41 | 12.36 ± 8.07 | 1.44 ± 1.21 | 6.58 ± 5.29 | 15.13 ± 11.68 | |
| NM(7) | 6.00 ± 8.00 | 6.23 ± 2.84 | 19.74 ± 12.73 | 1.86 ± 1.07 | 6.27 ± 1.94 | 15.92 ± 4.90 | |
| RM(4) | 2.25 ± 2.06 | 3.34 ± 3.11 | 8.21 ± 6.88 | 1.13 ± 0.85 | 2.80 ± 2.23 | 8.29 ± 7.75 | |
| UM(3) | 4.50 ± 0.87 | 7.75 ± 3.01 | 24.58 ± 11.96 | 0.17 ± 0.29 | 4.09 ± 7.09 | 8.19 ± 14.19 | |
| p value⁎ | 0.09 | 0.09 | 0.048 | 0.035 | 0.46 | 0.63 | |
Table showing area under the curve (AUC), maximum concentration of drug recorded (Cmax) and the corresponding time (Tmax) for Pantoprazole (PPZ) and Esomeprazole (EPZ).
a
All pharmacokinetic parameters have been given as mean ± SD wherever applicable.
⁎
p values were calculated using Kruskal Wallis test.