Table 5.
Intra-gastric pH of subjects for different phenotypes.
| Phenotype | Drug(n) | Baseline pH | pH on Day 6 |
|---|---|---|---|
| Poor metabolizer | Esomeprazole(2) | 2.45 ± 1.76 | 3.00 ± 2.82 |
| Pantoprazole(2) | 1.40 ± 0.70 | 5.25 ± 0.35 | |
| Normal metabolizer | Esomeprazole(1) | 0.40 | 3.40 |
| Pantoprazole(1) | 1.50 | 4.10 | |
| Intermediate metabolizer | Esomeprazole(1) | 2.00 | 4.10 |
| Pantoprazole(2) | 1.70 ± 0.14 | 6.15 ± 0.07 | |
| Rapid metabolizer | Esomeprazole(1) | 1.25 | 1.20 |
| Ultra-rapid metabolizer | Esomeprazole(1) | 2.00 | 2.40 |
| Pantoprazole(1) | 1.30 | 1.20 |
Table showing intra gastric pH values in subjects categorized into various groups. pH was recorded using a nasal probe before and after administering PPI for 5 days. Values have been given as mean ± SD wherever applicable.