Table 2.
Suppressed genes in miR-944 transfected cells with roles in cell migration and invasion
| aGene symbol | bProtein name | Fold change | Associated function in cancer | miR-944 binding sitesc |
|---|---|---|---|---|
| NEK2 | Serine/threonine-protein kinase Nek2 (Never in mitosis A-related kinase 2) | -3.09 | Nek2 is up-regulated in pre-invasive in situ ductal and invasive breast carcinomas | 0 |
| ADAM28 | Disintegrin and metalloproteinase domain-containing protein 28 | -3.05 | ADAM28 is overexpressed in lymph node metastasis in lung carcinomas | 0 |
| PAK1 | Serine/threonine-protein kinase p21-activated kinase1 | -3.03 | PAK1 induces colorectal cancer metastasis by ERK activation and FAK-Ser901 phosphorylation | 0 |
| FGFR2 | Fibroblast growth factor receptor 2 | -3.01 | Overexpression of FGFR2, a transforming oncogene in human mammary epithelial cells, leads to invasive phenotype | 0 |
| RAC1 | Ras-related C3 botulinum toxin substrate 1 | -2.98 | RAC1 activation mediates Twist1-induced cancer cell migration | 0 |
| ANXA7 | Annexin A7 | -2.67 | Decreased ANXA7 expression is associated with high invasive potential in multiple tumors | 0 |
| NCOA4 | Nuclear receptor coactivator 4 | -2.34 | NCOA4 (ARA70) promotes cell growth and invasion in prostate cancer | 0 |
| MMP14 | matrix metallopeptidase 14 | -2.3 | MMP14 controls invasiveness of aggressive breast tumours, and is associated with clinical outcome | 1 |
| PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 | -2.23 | Promotes mitosis and migration of human breast cancer-derived cells | 0 |
| PRKCA | Protein kinase C, alpha | -1.96 | PRKCA regulate Ets1 in invasive breast cancer | 1 |
| SIAH1 | E3-ubiquitin protein ligase | -1.90 | Promotes migration and invasion of glioma cells by regulating HIF-1 under hypoxia. Impairs tumor growth and metastasis inbreast cancer | 1 |
| PTP4A1 | Protein tyrosine phosphatase type IVA, member 1 | -1.80 | PTP4A1 is related to the lymph node metastasis of colonic adenocarcinoma. Promotes cell motility, invasion and metastasis of ovarian and lung cancer cells. | 1 |
| DEK | DEK | -1.58 | DEK oncogene regulates motility and invasion in breast cancer | 0 |
| NOTCH2 | Neurogenic locus notch homolog protein 2 | -1.58 | Plays a role in invasive breast cancer | 0 |
| TRIM32 | E3 ubiquitin-protein ligase TRIM32 (Tripartite motifcontaining 32) | -1.53 | TRIM32 oncogene promotes tumor growth, metastasis, and resistance to anticancer drugs via degradation of Ablinteractor 2 | 1 |
aGenBank databases. bUniprot database (Recommended name). cPredicted by TargetScan