Table 3.
Median hormone concentrations (10–90th percentiles) overall and by parity a
| All women (n = 50) |
Primiparous (n = 25) |
Multiparous (n = 25) |
pMW c | |
|---|---|---|---|---|
| Estradiol (ng/mL) | ||||
| 1st trimester | 2.18 (1.16–3.59) | 2.11 (1.19–4.00) | 2.42 (1.12–3.12) | 0.92 |
| 2nd trimester | 9.71 (5.33–15.1) | 10.3 (5.20–14.8) | 9.45 (5.46–15.3) | 0.64 |
| 3rd trimester | 20.4 (12.8–32.9) | 22.3 (13.6–35.6) | 19.5 (12.8–31.5) | 0.71 |
| Median %-change b | 876 % | 858 % | 889 % | |
| Estrone (ng/mL) | ||||
| 1st trimester | 0.93 (0.41–1.72) | 0.71 (0.35–2.07) | 1.11 (0.48–1.60) | 0.14 |
| 2nd trimester | 4.28 (1.99–8.54) | 3.96 (1.64–8.84) | 4.56 (2.77–6.88) | 0.85 |
| 3rd trimester | 11.5 (3.70–18.9) | 10.4 (3.65–21.3) | 11.7 (3.77–17.8) | 0.92 |
| Median %-change b | 976 % | 919 % | 1053 % | |
| Progesterone (ng/mL) | ||||
| 1st trimester | 25.6 (16.6–40.7) | 27.3 (20.0–42.2) | 23.0 (13.5–37.8) | 0.03 |
| 2nd trimester | 48.1 (31.6–78.5) | 53.8 (37.8–85.2) | 42.1 (28.7–71.3) | 0.03 |
| 3rd trimester | 130 (72.6–200) | 138 (105–215) | 107 (60.2–163) | 0.007 |
| Median %-change b | 411 % | 422 % | 396 % | |
| Testosterone (ng/mL) | ||||
| 1st trimester | 0.96 (0.42–1.98) | 1.34 (0.78–2.15) | 0.66 (0.36–1.11) | <0.0001 |
| 2nd trimester | 1.19 (0.55–3.35) | 1.98 (1.05–3.96) | 0.73 (0.44–1.43) | <0.0001 |
| 3rd trimester | 1.32 (0.50–4.07) | 2.56 (0.54–6.06) | 0.71 (0.50–2.41) | 0.0008 |
| Median %-change b | 61 % | 74 % | 38 % | |
| Prolactin (ng/mL) | ||||
| 1st trimester | 28.8 (16.3–57.6) | 32.6 (19.8–63.3) | 27.6 (10.6–47.0) | 0.10 |
| 2nd trimester | 126 (54.9–206) | 105 (49.0–181) | 139 (72–206) | 0.32 |
| 3rd trimester | 216 (124–318) | 177 (115–258) | 225 (133–320) | 0.12 |
| Median %-change b | 570 % | 449 % | 795 % | |
| OPG (pmol/L) | ||||
| 1st trimester | 3.79 (2.63–5.90) | 3.45 (2.71–5.61) | 3.93 (2.37–5.99) | 0.21 |
| 2nd trimester | 5.26 (3.10–7.91) | 4.96 (3.28–7.15) | 6.01 (3.10–9.01) | 0.17 |
| 3rd trimester | 9.74 (4.44–17.5) | 8.18 (4.09–20.3) | 10.5 (5.59–16.4) | 0.12 |
| Median %-change b | 143 % | 112 % | 162 % | |
| sRANKL (pmol/L) | ||||
| 1st trimester | 0.43 (0.10–0.81) | 0.32 (0.06–0.92) | 0.56 (0.31–0.74) | 0.04 |
| 2nd trimester | 0.43 (0.10–0.91) | 0.31 (0.06–1.05) | 0.51 (0.27–0.81) | 0.26 |
| 3rd trimester | 0.43 (0.20–0.82) | 0.41 (0.14–0.95) | 0.43 (0.30–0.72) | 0.35 |
| Median %-change b | 8 % | 30 % | −14 % | |
a Conversion from ng/ml to nmol/l (SI units): estradiol*3.671, estrone*3.699, progesterone*3.18, testosterone*3.467, and prolactin*0.04348
b Median %-change between 1st and 3rd trimester
c p-value obtained from the Mann–Whitney-U test comparing primi- and multiparous women