Table 4.
Percentage changes [95 % confidence intervals] in 3rd trimester hormone concentrations given 1st and 2nd trimester concentrations and maternal and newborn characteristics a
| Estradiol | Estrone | Progesterone | Testosterone | Prolactin | OPG | sRANKL | |
|---|---|---|---|---|---|---|---|
| A) | |||||||
| 1st trimester hormone only | 26 [7, 50] | 31 [7, 62] | 34 [10, 63] | 71 [36, 115] | 16 [3, 31] | 33 [13, 57] | 52 [35, 71] |
| Adjusted R2 - basic model | 16 % | 10 % | 13 % | 31 % | 10 % | 18 % | 58 % |
| 1st trimester hormone | |||||||
| Age at blood draw | −2 [−5, 1] | −1 [−7, 4] | 0 [−3, 3] | −2 [−8, 5] | 1 [−2, 4] | −2 [−5, 2] | −3 [−7, 1] |
| Smoking | 42 [11, 82] | 33 [−20, 113] | 14 [−13, 45] | 85 [2, 236] | −41 [−82, −9] | −12 [−61, 29] | −27 [−103, 25] |
| Parity | −5 [−28, 16] | −4 [−49, 38] | −24 [−50, −3] | −57 [−158, 4] | 32 [9, 60] | 21 [−6, 55] | −18 [−58, 14] |
| Child sex | 27 [4, 54] | 11 [−30, 59] | 16 [−4, 40] | 11 [−39, 71] | 1 [−23, 27] | 21 [−7, 56] | 0 [−34, 34] |
| Birth length [per 5 cm] | −13 [−40, 9] | −39 [−102, 5] | −5 [−29, 17] | 12 [−41, 76] | 21 [−2, 51] | 32 [0, 72] | 12 [−23, 56] |
| Birth weight [per 100 g] | −1 [−2, 1] | −1 [−5, 2] | −1 [−2, 1] | 0 [−4, 5] | 2 [0, 4] | 2 [0, 5] | 1 [−2, 4] |
| Adjusted R2 - full model | 46 % | 23 % | 20 % | 39 % | 22 % | 18 % | 56 % |
| B) | |||||||
| 2nd trimester hormone only | 57 [35, 83] | 76 [45, 114] | 57 [36, 82] | 103 [72, 140] | 44 [29, 60] | 64 [36, 98] | 61 [45, 78] |
| Adjusted R2 - basic model | 42 % | 40 % | 45 % | 63 % | 55 % | 36 % | 71 % |
| 2nd trimester hormone | |||||||
| Age at blood draw | −1 [−3, 2] | 0 [−4, 5] | 0 [−2, 2] | 1 [−4, 6] | −1 [−3, 1] | −3 [−7, 0] | −3 [−6, 1] |
| Smoking | 27 [2, 57] | 21 [−22, 79] | 20 [0, 44] | 59 [1, 151] | −26 [−50, −5] | −1 [−41, 37] | −21 [−83, 25] |
| Parity | −2 [−21, 16] | 2 [−30, 37] | −17 [−36, 0] | −8 [−63, 40] | 16 [1, 34] | 12 [−12, 42] | −8 [−39, 19] |
| Child sex | 8 [−9, 27] | −8 [−44, 24] | 4 [−12, 22] | −10 [−52, 27] | 2 [−15, 18] | 7 [−18, 35] | −4 [−34, 23] |
| Birth length [per 5 cm] | −10 [−31, 9] | −20 [−63, 14] | −11 [−31, 6] | 11 [−26, 57] | 18 [1, 38] | 14 [−14, 48] | 24 [−5, 62] |
| Birth weight [per 100 g] | −1 [−3, 1] | −1 [−4, 2] | −1 [−2, 0] | 0 [−3, 3] | 1 [0, 2] | 1 [−1, 4] | 2 [−1, 4] |
| Adjusted R2 - full model | 51 % | 39 % | 54 % | 70 % | 67 % | 31 % | 70 % |
| C) | |||||||
| 1st & 2nd trimester hormones | |||||||
| Adjusted R2 - basic model | 45 % | 38 % | 45 % | 61 % | 57 % | 37 % | 70 % |
| Adjusted R2 - full model | 55 % | 38 % | 52 % | 67 % | 69 % | 32 % | 69 % |
a All models include 1st or 2nd trimester hormone concentration and the respective gestational age