Table 6.
Median hormone concentrations (10th-90th percentiles) and median change by trimester in 21 consecutive pregnancies a
| Pregnancy 1 | Pregnancy 2 | Median change | pWS b | |
|---|---|---|---|---|
| Estradiol (ng/mL) | ||||
| 1st trimester | 2.32 (1.27–3.76) | 1.98 (1.11–3.58) | −0.3 (−1.3; −1.3) | 0.10 |
| 2nd trimester | 9.00 (5.91–13.3) | 7.96 (5.21–13.2) | −0.3 (−0.9; 1.3) | 0.18 |
| 3rd trimester | 22.6 (16.2–34.2) | 20.0 (14.2–32.0) | −0.2 (−0.9; 0.5) | 0.07 |
| Estrone (ng/mL) | ||||
| 1st trimester | 0.73 (0.42–1.60) | 0.73 (0.28–1.50) | −0.2 (−1.1; 0.5) | 0.11 |
| 2nd trimester | 4.19 (2.03–6.76) | 3.90 (1.67–8.17) | −0.2 (−1.0; 0.4) | 0.10 |
| 3rd trimester | 8.00 (4.34–17.1) | 7.80 (3.32–12.2) | −0.3 (−0.6; 0.2) | 0.08 |
| Progesterone (ng/mL) | ||||
| 1st trimester | 30.6 (22.1–47.4) | 31.2 (22.9–45.0) | 0 (−0.5; 0.6) | 0.65 |
| 2nd trimester | 56.9 (39.3–85.3) | 62.3 (40.4–78.7) | −0.1 (−0.8; 1.0) | 0.96 |
| 3rd trimester | 161 (127–207) | 165 (123–225) | 0.1 (−0.7; 0.5) | 0.55 |
| Testosterone (ng/mL) | ||||
| 1st trimester | 0.84 (0.52–1.38) | 0.78 (0.46–1.43) | 0 (−1.2; 0.5) | 0.31 |
| 2nd trimester | 1.10 (0.68–1.67) | 1.02 (0.55–1.50) | −0.2 (−0.9; 0.6) | 0.09 |
| 3rd trimester | 1.04 (0.60–2.88) | 0.89 (0.60–1.45) | −0.4 (−1.0; 0.2) | 0.002 |
a Conversion from ng/ml to nmol/l (SI units): estradiol*3.671, estrone*3.699, progesterone*3.18, testosterone*3.467, and prolactin*0.04348
b p-value obtained from the Wilcoxon signed rank sum test