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. 2016 Jul 4;16:391. doi: 10.1186/s12885-016-2464-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Axial contrast-enhanced MRI brain images showing a right parietal delayed radiation necrosis (15 mm) after SRS, surgery, and SRT at initiation of T-DM1 (a), (b) enlarging heterogeneous enhancement (30 mm) at 12 months (c) rapid progression of nodular lesion (48 mm) at 15 months after initiation of T-DM1 therapy. Precontrast CT scan shows high density area in this lesion (d). Perfusion CT (e) showing an area of low CBV. Photomicrographs of H-E (f), CD31 (g) and EVG (h) stains. The scale bar represents 500 μm for panel. Hemorrhage and dilated blood containing spaces are shown (f). CD31 immunostaining (g) shows vascular structures of variable sizes. However, EVG stain (g) indicates no elastic or collagenous fibers surrounding vascular lumina, in contrast to purplish-brown collagen and black elastic fibers comprising septa between hemorrhagic area (left) and viable cerebral tissue (lower right)