Table 1.

Case–control studies reporting plasma or serum peroxidation biomarkers and Total Antioxidant Capacity in psoriasis: association with inflammation and lipid profile

Ref.	Case/control	Peroxidation	TAC	Inflammation	Lipid profile
[18]	100/100	↑ MDA			↑ CHOL, LDL
					↔ HDL, TG
[19]	100/100	↑ MDA		↑VAP-1	↑ CHOL, LDL
					↔ HDL, TG
[20]	25/20: 10/10 smokers	↑ MDA
	15/10 non-smokers	↑ MDA
[21]	29/18	↑MDA/TBARS	↓	↑ROS
[22]	30/10: 10 mild		↔
	10 moderate		↔
	10 severe		↔
[23]	35/25	↑ MDA	↓
[24]	32/32	↑ MDA
[25]	8/8	↑ peroxides	↓
[26]	34/37	↑ TBARS, oxLDL	↔	↑ CRP	↑ CHOL, LDL, TG
					↓ HDL
[27]	73/38	↑ TBARS	↔	↑CRP
[28]	67/35	↑ TBARS
[29]	58/45	↑ MDA	↓
[30]	54/62: 28/16 smokers	↑ TOS	↓		↔ CHOL, LDL, HDL, TG
	26/46 non-smokers	↑ TOS	↓		↔ CHOL, LDL, HDL, TG
[31]	23/25: 12 mild (1)	↑ peroxides and dienes		↔ CRP	↔ CHOL, LDL, HDL, TG
	11 severe (2)	↑ peroxides and dienes		↔ CRP	↔ CHOL, LDL, HDL, TG
[32]	55/20: 11 mild,	↑ MDA	↓
	20 moderate	↑ MDA	↓
	24 severe	↑ MDA	↓
[33]	7/6		↑
[34]	16/16	↑ TBARS	↓
[35]	59/40	↑ MDA		↑ IL-6
[36]	90/30: 30 mild	↑ MDA	↓
	30 moderate	↑ MDA	↓
	30 severe	↑ MDA	↓
[37]	39/25	↑ TOC	↓
[38]	60/47	↑ peroxides	↓
[39]	32/20	↔ TBARS
[40]	40/20	↑ peroxides
[41]	127/389	↑ peroxides
[42]	100/100: 29 Mild	↑ MDA			↑ CHOL, LDL
					↔ HDL, TG
	60 Moderate	↑ MDA			↑ CHOL, LDL
					↔ HDL, TG
	11 Severe	↑ MDA			↑ CHOL, LDL
					↔ HDL, TG
[43]					↑ CHOL, TG
	30/33	↑ oxLDL		↑ ESR	↔ LDL
					↓ HDL
[44]	24/26	↑ MDA		↑ IL-8
[45]	90/90: 30 mild	↑ MDA
	30 moderate	↑ MDA
	30 severe	↑ MDA
[46]	40/40: 34 remission	↔ MDA
	6 acute	↑ MDA
[47]	60/30: 30 inactive psoriasis	↑ TBARS	↓		↔CHOL, LDL, TG
					↓ HDL
	30 active psoriasis	↑ TBARS	↓		↑ CHOL, LDL, TG ↓ HDL
[48]	60/40: 30 inactive psoriasis	↑ TBARS	↔	↑ CRP
	30 active psoriasis	↑ TBARS	↓	↑ CRP
[49]	48/40: 24 inactive psoriasis	↑ TBARS	↔		↔CHOL, LDL, TG
					↓ HDL
	24 active psoriasis	↑ TBARS	↓		↑ CHOL, LDL, TG ↓ HDL
[50]	33/36		↔
[51]	23/23	↑ MDA
[52]	45/45	↑ MDA			↑ CHOL, LDL, ↔ HDL, TG
[53]	40/47	↑ TOS	↓
[54]	30/23	↔ MDA	↔		↔ CHOL, LDL, HDL, TG
[55]	52/25: 25 with MS	↔ TOS	↔		↑ CHOL, LDL, TG
					↓ HDL
	27 without MS	↔ TOS	↔		↔ CHOL, LDL, HDL, TG
[56]	35/35	↑ MDA, oxLDL	↓	CRP, ESR↑	↑ CHOL, LDL, TG ↓ HDL
[57]	67/35	↑ TBARS
[58]	22/22	↔ MDA

CHOL: cholesterol; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; HDL: high-density lipoprotein; IL: interleukin; LDL: low-density lipoprotein; MDA: malondialdehyde; MS: metabolic syndrome; oxLDL: oxidized low-density lipoprotein; ROS: reactive oxygen species; TAC: total antioxidant capacity; TBARS: thiobarbituric acid reactive substance; TG: triglycerides; TOC: total oxidant capacity, also named total oxidant status (TOS); VAP-1: vascular adhesion protein-1; ↑: increased; ↓: decreased; ↔: unchanged