Table 4.
Baseline parameters as predictors of residual PH 1 year post PEA
| Univariate model | Multivariate model* | |||
|---|---|---|---|---|
| Hazard ratio (95 % confidence interval) | p-value | Hazard ratio (95 % confidence interval) | p-value | |
| 6MWT | ||||
| 6MWD (m) | 1.01 [0.99–1.01] | 0.44 | - | - |
| Rest SpO2 (%) | 1.25 [0.94–1.67] | 0.11 | - | - |
| Peak SpO2 (%) | 0.96 [0.85–1.08] | 0.46 | - | - |
| Δ SpO2 (%) | 0.99 [0.86–1.16] | 0.96 | - | - |
| Rest HR (beats*min-1) | 0.99 [0.94–1.03] | 0.6 | - | - |
| Peak HR (beats*min-1) | 1.03 [0.99–1.06] | 0.19 | - | - |
| Δ HR (beats*min-1) | 1.10 [1.03–1.2] | 0.009 | - | - |
| HRR (%) | 1.06 [1.02–1.1] | 0.01 | 1.06 [0.99–1.14] | 0.08 |
| CPET | ||||
| Rest SpO2 (%) | 1.81 [0.86–3.76] | 0.12 | - | - |
| Peak SpO2 (%) | 1.02 [0.86–1.20] | 0.84 | - | - |
| Δ SpO2 (%) | 1.05 [0.86–1.27] | 0.66 | - | - |
| Rest HR (beats*min-1) | 0.96 [0.90–1.02] | 0.16 | - | - |
| Peak HR (beats*min-1) | 0.98 [0.95–1.01] | 0.25 | - | - |
| Δ HR (beats*min-1) | 0.99 [0.96–1.03] | 0.71 | - | - |
| HRR (%) | 1.00 [0.97–1.03] | 0.91 | - | - |
| Peak VO2 (ml/min/kg) | 0.95 [0.78–1.17] | 0.63 | - | - |
| RHC | ||||
| mPAP (mm Hg) | 1.07 [0.98–1.16] | 0.13 | - | - |
| RAP (mm Hg) | 1.01 [0.83–1.2] | 0.96 | - | - |
| PVR (dyne*s/cm5) | 1.01 [0.99–1.01] | 0.19 | - | - |
| CI (l/min/m2) | 1.10 [0.3–4.01] | 0.89 | - | - |
| PAWP (mm Hg) | 1.03 [0.89–1.2] | 0.67 | - | - |
| Echocardiography | ||||
| TAPSE (mm) | 0.90 [0.77–1.06] | 0.2 | - | - |
| PASP (mm Hg) | 1.03 [0.99–1.07] | 0.06 | - | - |
| Other | ||||
| Nt-pro BNP (pg/ml) | 1.00 [0.99–1.01] | 0.97 | - | - |
| WHO functional class | - | 0.39 | - | - |
| Jamieson-Type | ||||
| • I | Reference | Reference | ||
| • II | 4.2 [0.6–30.1] | 0.15 | 8.9 [0.7–116.4] | 0.096 |
| • III | 1.67 [0.28–3.57] | 0.58 | 5.02 [3.23–100] | 0.25 |
For abbreviations see Table 1. *: backward stepwise logistic regression including variables with a p-value <0.15 in the univariate model