Fig. 4.

Milder lung fibrosis in miR-155 knockout (KO) mice. a Percent survival rate by Kaplan-Meier, log-rank test. b Ashcroft lung score assessed by Masson’s trichrome staining. Lung gene expression by Nanostring of Arginase-1 (c) and tissue inhibitor of metalloproteinase-1 (TIMP1) (d). e Cluster of the most affected genes by the absence of miR-155 (blue). Data are expressed by counting gene expression on c and d. Each microRNA was z-score-normalized across all samples and scaled to red and blue (≥2 or ≤ –2, respectively) and white indicating a z score of zero. Analysis of variance; p < 0.05 was considered significant. WT wild-type, Bleo bleomycin