Table 4.
Risks of psychiatric disorders, suicide attempt and suicide in siblings of individuals with hypermobility syndrome (hypermobility syndrome siblings) compared with matched siblings to individuals without hypermobility syndrome (comparison siblings)
| Hypermobility syndrome siblings (n = 11,082) | Comparison siblings (n = 108,772) | |||
|---|---|---|---|---|
| n (%) | n (%) | RR (95 % CI) | RRa (95 % CI) | |
| Autism spectrum disorder | 66 (0.6) | 500 (0.5) | 1.3 (1.1–1.7) | 1.3 (1.1–1.7) |
| Bipolar disorder | 31 (0.3) | 269 (0.3) | 1.1 (0.8–1.6) | 1.2 (0.8–1.7) |
| ADHD | 124 (1.1) | 966 (0.9) | 1.3 (1.1–1.5) | 1.3 (1.1–1.5) |
| Depression | 343 (3.1) | 2,788 (2.6) | 1.2 (1.1–1.3) | 1.2 (1.1–1.3) |
| Suicide attempt | 270 (2.4) | 2,182 (2.0) | 1.2 (1.1–1.4) | 1.2 (1.1–1.4) |
| Suicide | 29 (0.3) | 230 (0.2) | 1.2 (0.9–1.7) | 1.3 (0.9–1.8) |
| Schizophrenia | 26 (0.2) | 184 (0.2) | 1.4 (0.9–2.0) | 1.3 (0.9–1.9) |
Associations are expressed as risk ratios (RR) and 95 % confidence intervals (95 % CIs) from conditional logistic regression
Note: statistically significant RR are bolded. RRa, risk ratios restricted to individuals born in Sweden