Table 4.

Metabolic differences in the brain of experimental vs control animals. Fold change is expressed as Experimental/Control. N=9 animals per group.

Super Pathway	Sub Pathway	Biochemical Name	Fold changes	p-value
Amino Acid	Creatine Metabolism	creatinine	0.91	0.0004
	Urea cycle; Arginine and Proline Metabolism	N-acetylarginine	0.87	0.0018
	Polyamine Metabolism	spermine	0.17	0.0032
		spermidine	0.34	0.0059
	Lysine Metabolism	N2-acetyllysine/N6-acetyllysine	0.89	0.009
	Phenylalanine and Tyrosine Metabolism	O-methyltyrosine	0.82	0.0152
	Urea cycle; Arginine and Proline Metabolism	citrulline	0.84	0.0264
		urea	0.8	0.0275
	Glutamate Metabolism	S-1-pyrroline-5-carboxylate	0.77	0.0399
		glutamate, gamma-methyl ester	0.88	0.0498
Carbohydrate	Aminosugar Metabolism	glucosamine-6-phosphate	0.84	0.0152
	Pentose Phosphate Pathway	6-phosphogluconate	0.72	0.0159
	Glycolysis, Gluconeogenesis, and Pyruvate Metabolism	1,5-anhydroglucitol (1,5-AG)	1.18	0.0173
		glucose 6-phosphate	0.74	0.0299
		fructose-6-phosphate	0.79	0.0338
Cofactors and Vitamins	Riboflavin Metabolism	flavin mononucleotide (FMN)	0.71	0.0101
	Pantothenate and CoA Metabolism	pantothenate	0.87	0.0299
	Hemoglobin and Porphyrin Metabolism	heme	0.62	0.0433
Lipid	Sterol	campesterol	0.85	0.0243
	Sphingolipid Metabolism	sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)*	1.11	0.0272
	Phospholipid Metabolism	1,2-distearoyl-GPC (18:0/18:0)	1.07	0.0276
	Lysolipid	2-stearoyl-GPE (18:0)*	1.41	0.0315
Nucleotide	Purine and Pyrimidine Metabolism	methylphosphate	0.86	0.0261
Peptide	Dipeptide	glycylvaline	1.31	0.0055
	Gamma-glutamyl Amino Acid	gamma-glutamyl-epsilon-lysine	0.62	0.0455
Xenobiotics	Food Component/Plant	gluconate	0.73	0.0271
		stachydrine	0.69	0.0379
		ergothioneine	0.63	0.0407