Table 6.
Metabolic changes in the heart of experimental vs control animals. Fold change is expressed as Experimental/Control. N=9 animals/group.
| Super Pathway | Sub Pathway | Biochemical Name | Fold changes | p-value |
|---|---|---|---|---|
| Amino Acid | Methionine, Cysteine, SAM and Taurine Metabolism | taurocyamine | 1.31 | 0.0174 |
| cystine | 1.39 | 0.0423 | ||
| Leucine, Isoleucine and Valine Metabolism | leucine | 1.13 | 0.0342 | |
| Urea cycle; Arginine and Proline Metabolism | N-delta-acetylornithine | 0.87 | 0.0373 | |
| Alanine and Aspartate Metabolism | N-acetylalanine | 1.16 | 0.0235 | |
| Carbohydrate | Glycolysis, Gluconeogenesis, and Pyruvate Metabolism | 1,5-anhydroglucitol (1,5-AG) | 1.26 | 0.0089 |
| pyruvate | 1.38 | 0.0496 | ||
| Advanced Glycation End-product | N6-carboxymethyllysine | 1.16 | 0.0292 | |
| Pentose Metabolism | ribonate | 1.27 | 0.0365 | |
| Cofactors and Vitamins | Nicotinate and Nicotinamide Metabolism | nicotinamide adenine dinucleotide reduced (NADH) | 2.03 | 0.0228 |
| Lipid | Monoacylglycerol | 2-oleoylglycerol (18:1) | 1.67 | 0.0132 |
| 2-palmitoleoylglycerol (16:1) | 2.35 | 0.0392 | ||
| 1-oleoylglycerol (18:1) | 1.98 | 0.0405 | ||
| Phospholipid Metabolism | 1-palmitoyl-2-linoleoyl-GPC (16:0/18:2) | 0.84 | 0.0303 | |
| 1-palmitoyl-2-linoleoyl-GPE (16:0/18:2) | 0.85 | 0.0431 | ||
| Fatty Acid, Keto | 1-dihomo-linoleoylglycerol (20:2) | 2.13 | 0.0414 | |
| Long Chain Fatty Acid | 10-nonadecenoate (19:1n9) | 1.45 | 0.0355 | |
| Sphingolipid Metabolism | sphingomyelin (d18:2/16:0, d18:1/16:1) | 1.16 | 0.0375 | |
| glycosyl-N-palmitoyl-sphingosine | 1.28 | 0.0441 | ||
| Fatty Acid, Dicarboxylate | undecanedioate | 1.24 | 0.0448 | |
| Diacylglycerol | 1-palmitoleoyl-3-oleoyl-glycerol (16:1/18:1) | 1.73 | 0.0465 | |
| Xenobiotics | Food Component/Plant | 4-ethylphenol glucuronide | 2.22 | 0.0146 |
| Benzoate Metabolism | 4-ethylphenylsulfate | 3.43 | 0.0149 |