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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Expert Rev Cardiovasc Ther. 2016 Feb 17;14(5):591–598. doi: 10.1586/14779072.2016.1147348

Figure 1.

Figure 1

The myofibroblast secretory phenotype found at the site of healing. This myofibroblast secretome includes the de novo generation of angiotensin II and subsequent induction of collagen synthesis by these cells. Included in the secretome is the expression of renin, ACE and AT1 receptors. Autocrine actions of angiotensin II, mediated via AT1 receptor binding, results in expression of fibrogenic TGF-β1 and CTGF to stimulate myofibroblast production of fibronectin, which forms a provisional scaffold for type I and type III collagen fibrillogenesis. Abbreviations: ACE, angiotensin-converting enzyme; AT1, angiotensin II type 1; CTGF, connective tissue growth factor; MMPs, matrix metalloproteinases; TGF-β1, transforming growth factor β1. Adapted from Weber KT, Sun Y, Bhattacharya SK, Ahokas RA, Gerling IC. Myofibroblast-mediated mechanisms of pathological remodelling of the heart. Nat Rev Cardiol. 2013;10:15-26.