Physical and chemical properties of the lipids influence the binding efficiency and the aggregation propensity of α-synuclein in the presence of model membranes. The energy of transfer of a lipid molecule from water to a bilayer (ΔG°tr,30
°C) (orange), the stoichiometry of α-synuclein:lipid binding (blue), and the half-time for the aggregation of α-synuclein (black) are plotted for each lipid system: DLPS [(12:0)2], DMPS [(14:0)2], DPPS [(16:0)2], POPS (16:0/18:1), and DOPS [(18:1)2]. The phase of each lipid systems in the presence of an excess of protein at 30 °C is indicated below the x axis.