Fig. 3.

Partial rescue of early B-cell development by an EμBCL2 transgene but not a BCR transgene. (A) Flow-cytometric plots of major B-cell populations in bone marrow (Left), peritoneum (Center), and spleen (Right) of wild-type and Fnip1 mutant mice with or without an EμBCL2 transgene. (B and D) Absolute numbers of cells in corresponding Hardy fractions (A, B220⁺CD43⁺BP-1⁻CD24⁻; B, B220⁺CD43⁺BP-1⁻CD24⁺; C+C′, B220⁺CD43⁺BP-1⁺CD24⁺; D, B220⁺CD43⁻IgM⁻IgD⁻; E, B220⁺CD43⁻IgM⁻IgD+; and F, B220⁺CD43⁻IgM⁺IgD⁺) in the presence or absence of an EμBCL2 or BCR transgene. (C and E) Absolute numbers of B220⁺ splenocytes. Plots in A are representative of five mice per genotype. Symbols in B and D represent the means (± SEM). Each symbol in C and E represents an individual mouse. Bars indicate means ± SEM.