Figure 9.
(A) The 3D color model at the top depicts the location of the brains that comprise the primary olfactory system in the vole. These areas have been coalesced into a single volume (yellow) as shown in the lower 3D images for ambient air (n = 6) and a sequence of novel odors comprised of rose (methyl benzoate), almond (benzaldehyde), and banana (isoamyl acetate) (n = 7). All odors (Sigma Chemical) were prepared as 1% solutions in distilled water. Localization of the significantly changed positive BOLD voxels comprising the composite average from the voles in each experimental group are shown in red. (B) The table at the bottom lists brain regions rank ordered by statistical significance between subjects presented with ambient air and those presented with the sequence of novel odors.
| B. Region of Interest(ROI) | Air | Rose/Almond/Banana | P value | ||||
| median | max | min | median | max | min | ||
|
| |||||||
| anterior olfactory area | 0 | 4 | 0 | 2 | 29 | 1 | 0.015 |
| orbital cortex | 0 | 2 | 0 | 2 | 17 | 0 | 0.028 |
| perirhinal cortex | 0 | 2 | 0 | 10 | 12 | 0 | 0.029 |
| granular cell layer olfactory bulb | 0.5 | 18 | 0 | 6 | 46 | 4 | 0.03 |
| CA1 | 0 | 1 | 0 | 1 | 13 | 0 | 0.034 |
| auditory cortex | 0 | 2 | 0 | 7 | 19 | 0 | 0.036 |
| glomerular layer olfactory bulb | 3.5 | 7 | 0 | 8 | 41 | 3 | 0.044 |
| entorhinal cortex | 1 | 7 | 0 | 3 | 36 | 2 | 0.051 |