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. 2016 Mar 5;2(1):dvw002. doi: 10.1093/eep/dvw002

Figure 2.

Figure 2

epigenetic and genetic cascade of events (arrows) from a stem cell state to a differentiated adult state involved in development. A normal or environmentally modified state promotes genome alterations associated with an increase susceptibility for disease and phenotypic variation. The critical window of early development is when environmental factors have the ability to alter the epigenome (modified from [ 71 ])