Table 3.
Cumulative Incidence of Site-Specific First Breast Cancer Events by Year From Random Assignment
| Event | Cumulative Incidence (%; SE) | ||||
|---|---|---|---|---|---|
| Year 5 | Year 10 | Year 15 | Year 20 | Year 25 | |
| Local only | |||||
| ER positive | 8.8 (0.7) | 11.2 (0.7) | 11.9 (0.8) | 12.5 (0.8) | 12.6 (0.8) |
| ER negative | 6.9 (0.8) | 8.0 (0.8) | 8.1 (0.8) | 8.3 (0.8) | 8.3 (0.8) |
| Contralateral breast ± local | |||||
| ER positive | 2.2 (0.3) | 3.9 (0.5) | 5.1 (0.5) | 6.2 (0.6) | 6.5 (0.6) |
| ER negative | 1.3 (0.3) | 2.7 (0.5) | 3.8 (0.6) | 5.3 (0.7) | 6.2 (0.8) |
| Regional ± above | |||||
| ER positive | 5.0 (0.5) | 6.2 (0.6) | 7.0 (0.6) | 7.3 (0.6) | 7.5 (0.6) |
| ER negative | 9.0 (0.8) | 10.0 (0.9) | 10.0 (0.9) | 10.0 (0.9) | 10.1 (0.9) |
| Distant ± above | |||||
| ER positive | 23.4 (1.0) | 31.9 (1.1) | 35.0 (1.1) | 37.4 (1.2) | 38.3 (1.2) |
| ER negative | 27.1 (1.3) | 31.8 (1.4) | 33.4 (1.4) | 34.1 (1.4) | 35.3 (1.5) |
NOTE. Data are shown as percentage (SE).
Abbreviation: ER, estrogen receptor.