Table 3.
Univariable and Multivariable Cox Proportional Hazards Models for Time to Sensorineural Hearing Loss Onset
| Variable | Univariable Model | Multivariable Model | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Continuous variable | ||||||
| Age at RT (years) | 0.87 | 0.78-0.98 | .0189 | 0.93 | 0.85-1.02 | .1153 |
| CRD (Gy) | 1.08 | 1.04-1.12 | < .001 | 1.07 | 1.04-1.11 | .002 |
| Shunt status (yes) | — | — | 2.00 | 1.06-3.75 | .0321 | |
| Categorical variable | ||||||
| Age at RT (< 3 years) | 3.95 | 1.96-7.93 | .001 | 2.32 | 1.21-4.46 | .0117 |
| CRD (Gy) | — | — | 1.07 | 1.03-1.11 | .003 | |
| Sex (male) | 1.31 | 0.65-2.65 | .4493 | — | — | |
| Shunt status (yes) | 2.27 | 1.13-4.56 | .0207 | 2.02 | 1.07-3.78 | .0290 |
| No. surgeries (> 1) | 1.21 | 0.58-2.52 | .6115 | — | — | |
| Tumor location (infratentorial) | 3.47 | 1.63-7.38 | .0012 | — | — | |
Abbreviations: —, not applicable; CRD, cochlear radiation dose; HR, hazard ratio; RT, radiation therapy.