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Active site conformation in the ternary hpol η insertion step complex with dTTP opposite 1,N6-ϵdA. A, view into the DNA major groove; B, rotated by 90° and viewed perpendicular to the thymine and adduct base planes (ϵdA:dTTP, Tables 1 and 7). Selected active site residues are colored by atom with carbon atoms shown in maroon (1,N6-ϵdA), orange (incoming dTTP), purple (Arg-61 and Gln-38 from the finger domain), or magenta (Asp/Glu coordinating to Ca2+; pink spheres).
