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Twinkle DNA binding to replication fork structures. A–D, indicated concentration of Twinkle hexamer was incubated with the indicated replication fork DNA substrates 1–4 (0.5 nm) at 37 °C for 30 min as described under “Experimental Procedures.” DNA species from binding mixtures were resolved on non-denaturing 5% polyacrylamide gels. Representative images from EMSA of at least three independent experiments are shown.
