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SEM on samples Collagen-Ph1 (a), Collagen-Ph1.5 (b), Collagen-EDC10 (c) and Collagen-EDC60 (d), following 1-week incubation in PBS (pH 7.4, 25 °C). Retrieved EDC-crosslinked samples present damaged surface, providing supporting evidence of hydrolytic degradation taking place in these materials. The extent of surface damage seems to be directly related to the degree of crosslinking. In contrast to that, Ph-crosslinked samples reveal no detectable damage on their surfaces.
