TABLE 1.

Differential scanning fluorimetry binding data for CPI703, CPI571, CPI644, and CPI644-(−) on isolated bromodomains

The values ± S.D. are shown.

Protein	CPI703	CPI571	CPI644	CPI644-(−)
ASH1L	0.00 ± 0.73	−0.35 ± 0.40	−0.64 ± 0.25	−0.23 ± 0.88
BAZ1A	−0.12 ± 0.20	0.00 ± 0.00	−0.12 ± 0.20	−0.23 ± 0.20
BAZ2B	−0.12 ± 0.40	0.23 ± 0.53	0.12 ± 0.00	−0.23 ± 0.35
BPTF	0.46 ± 0.40	0.46 ± 0.53	0.58 ± 0.20	0.46 ± 0.72
BRD1	0.23 ± 0.00	0.46 ± 0.20	0.46 ± 0.20	0.23 ± 0.00
BRD4	0.70 ± 0.35	0.00 ± 0.00	1.39 ± 0.70	0.12 ± 0.20
BRD8	0.52 ± 0.25	0.46 ± 0.20	0.87 ± 0.25	0.35 ± 0.35
BRD9	0.93 ± 0.53	0.46 ± 0.53	0.70 ± 0.35	0.23 ± 0.20
BRG1	0.00 ± 0.00	0.35 ± 0.35	0.12 ± 0.20	0.12 ± 0.40
BRPF1	0.23 ± 0.00	−0.12 ± 0.00	−0.12 ± 0.35	−0.46 ± 0.35
BRPF3	0.35 ± 0.35	0.00 ± 0.49	0.46 ± 0.20	0.35 ± 0.60
CBP	5.80 ± 1.39	0.58 ± 0.00	8.70 ± 1.22	1.28 ± 0.35
CECR2	0.06 ± 0.25	0.06 ± 0.25	0.12 ± 0.20	0.93 ± 0.00
GCN5	0.00 ± 0.20	0.00 ± 0.20	−0.12 ± 0.20	−0.12 ± 0.20
MLL	0.00 ± 0.20	0.58 ± 0.35	0.70 ± 0.53	0.46 ± 0.20
PCAF	0.81 ± 0.20	0.35 ± 0.35	−0.23 ± 0.53	0.00 ± 1.04
TAF1 BD1-BD2	0.35 ± 0.00	0.46 ± 0.20	0.23 ± 0.20	0.35 ± 0.00
TRIM24	0.23 ± 0.20	0.23 ± 0.20	0.23 ± 0.20	0.00 ± 0.00
WDR9	0.23 ± 0.20	0.12 ± 0.00	0.12 ± 0.00	0.12 ± 0.00