FIGURE 7.

Intermolecular and intramolecular side chain-side chains interactions in HIV-1 capsid protein assemblies. A, intermolecular dimerization interface, involving helix 9 segments of interacting CTD domains from different CA molecules (green and cyan) around local 2-fold symmetry axes. B, intramolecular contacts of helices 1, 2, and 3 within a single NTD domain (purple). Structures in panels A and B are present in crystalline WT-CA (PDB file 4XFX), and may be somewhat different in WT-CA tubes, R18L-CA spheres, and R18L-CA sheets.