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A model on transcriptional regulation of Usp25. LPS or viral infection induces expression of type I IFNs. Type I IFNs bind to IRNAR1 and IRNAR2 to trigger activation of ISGF3, which binds to the promoter of IRF7 and activates expression of IRF7. The de novo synthesized IRF7 is phosphorylated by TBK1 or IKKϵ and binds to the two IRF binding sites in USP25 promoter to drive transcription of IRF7.
