FIGURE 7.

Suppression of ezrin expression and its pharmacological inhibition results in increased mRNA levels of integrated stress response signature genes in both osteosarcoma and ESCC. The published data on mRNA expression levels of integrated stress response signature genes in ESCC cells following ezrin depletion (42, 43) were compared with those generated in this work using specific molecule inhibitors of ezrin and siRNA-mediated silencing of ezrin (*, p < 0.05: for microarray analysis, statistical significance between treatment versus control group was determined using ANOVA model (n = 5 biological replicates); for RT-qPCR experiments statistical significance between treatment versus control group (n = 3 technical replicates) was determined by an unpaired Student's t test; ns, non-significant).