TABLE 3.
Plasma pharmacokinetic parameters after i.v. administration of NSC305787 (240 μg/kg) in Balb/c mice
Pharmacokinetic parameters are as follows: Cmax is the maximum plasma concentration; Tmax is the time to reach maximum plasma concentration; AUC is the area under the compound concentration versus time; T½ is the elimination half-life; V is the volume of distribution; and Cl is the clearance.
| Parameter | Value |
|---|---|
| Dose/route | 240 μg/kg IV |
| Tmax | 0.03 h |
| Cmax | 195.1 ng/ml |
| AUC14h | 228.5 ng·h/ml |
| AUCinf | 415.3 ng·h/ml |
| T½ | 13.6 h |
| V | 11.3 liter/kg |
| Cl | 9.6 ml/min/kg |