TABLE 4.
List of genes that were commonly up-regulated in response to NSC305787 and NSC668394 treatment
| Probe set | Gene title | Fold changea |
UniGene ID | |
|---|---|---|---|---|
| NSC305787 | NSC668394 | |||
| ILMN_1677511 | Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2) | 2.66 | 4.12 | Hs.196384 |
| ILMN_2374865 | Activating transcription factor3 (ATF3) | 2.51 | 3.11 | Hs.460 |
| ILMN_1676984 | DNA damage-inducible transcript3 (DDIT3) | 2.48 | 3.13 | Hs.505777 |
| ILMN_1661599 | DNA damage-inducible transcript4 (DDIT4) | 2.38 | 4.94 | Hs.744875 |
| ILMN_2376403 | TSC22 domain family, member3 (TSC22D3) | 1.99 | 3.92 | Hs.522074 |
| ILMN_2374159 | Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member1 (HERPUD1) | 1.92 | 2.46 | Hs.146393 |
| ILMN_1781285 | Dual specificity phosphatase1 (DUSP1) | 1.83 | 1.70 | Hs.171695 |
| ILMN_1800512 | Heme oxygenase (decycling) 1 (HMOX1) | 1.81 | 36.0 | Hs.517581 |
| ILMN_2188862 | Growth differentiation factor 15 (GDF15) | 1.71 | 2.24 | Hs.616962 |
| ILMN_1701361 | Leucine-rich adaptor protein 1-like (chromosome 9 open reading frame 150, C9orf150) (LURAP1L) | 1.63 | 2.18 | Hs.445356 |
| ILMN_1787815 | Tribbles homolog 3 (Drosophila) (TRIB3) | 1.61 | 3.35 | Hs.516826 |
| ILMN_1659936 | Protein phosphatase 1, regulatory subunit 15A (PPP1R15A) | 1.61 | 1.96 | Hs.631593 |
| ILMN_1773742 | DnaJ (Hsp40) homolog, subfamily B, member 9 (DNAJB9) | 1.56 | 2.86 | Hs.741182 |
| ILMN_1679041 | Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 (SLC3A2) | 1.56 | 2.24 | Hs.502769 |
| ILMN_1784602 | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A) | 1.51 | 1.67 | Hs.370771 |
| ILMN_1713505 | Niemann-Pick disease, type C1 (NPC1) | 1.58 | 1.50 | Hs.715623 |
a p < 0.05. The data represent all commonly up-regulated genes (1.5-fold) from microarray analysis of MG63.3 human osteosarcoma cells after treatment with anti-ezrin compounds NSC305787 and NSC668394.