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. 2016 Apr 29;291(25):13271–13285. doi: 10.1074/jbc.M115.709386

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — DN-CLIM regulates noncoding RNA H19. A, view of DN-CLIM ChIP-Seq peaks and wig files at the H19/Igf2 locus. The lowest panel shows DNase hypersensitivity at the H19/Igf2 locus (DHS) in G1E cells. Black boxes 1–4 represent CLIM binding regions selected for further analyses. B, expression of H19 across mouse cornea development and aging. C, expression of H19 in WT and DN-CLIM (DNC) corneas at P7 (n = 4 WT and 6 DNC). D, expression of H19 in empty vector (EV)- and DN-CLIM (DNC)-transfected human corneal epithelial cells (n = 6 empty vector and 4 DN-CLIM). E, MTT cell proliferation assays for cells transfected with scrambled control or siH19 (n = 6 per condition). F, MTT cell proliferation assays for cells transfected with the indicated constructs (n = 6 per condition). *, p < 0.05; **, p < 0.01. Error bars represent S.E.