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. 2016 Apr 29;291(25):13271–13285. doi: 10.1074/jbc.M115.709386

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — H19 and DN-CLIM regulate a shared set of genes in human corneal epithelial cells. A, GO analysis for genes down-regulated 1.5-fold or more in siH19 compared with scrambled control and for genes up-regulated 1.5-fold or more in siH19 compared with scrambled control (p < 0.01, n = 3). B, overlap of siH19-affected genes in primary human cornea epithelial cells and DN-CLIM-affected genes in P3 mouse cornea. C, GO analysis for genes affected by both siH19 and DN-CLIM. D, GO analysis for genes down-regulated by both siH19 and DN-CLIM. E, overlap of genes affected by both siH19 and DN-CLIM with genes that have a nearby CLIM peak. F, estrogen receptor motifs in DN-CLIM-bound regions at the H19 gene locus. G, ChIP-qPCR with CLIM1/2 at the indicated regions of the H19 locus (see Fig. 7A). H, ChIP-qPCR with ERα at the indicated regions of the H19 locus. GEO accession number, GSE80387. Error bars represent S.E. ncRNA, noncoding RNA; Neg, negative control region.