TABLE 3.
Summary of O-glycoproteins and O-glycosites identified in EBV
| Uniprot IDa | Protein name | Function | Total sites | Unambiguous sites | T (Hex-HexNAc) | Tn (HexNAc) | List of O-glycosylated amino acid positionsb |
|---|---|---|---|---|---|---|---|
| EBV total | 41 | 31 | 16 | 39 | |||
| P0C763 | gB | Fusion (76) | 5 | 5 | 3 | 5 | 24, 33, 34, 458, 621 |
| P0C6Z3 | gN | Egress, assembly (79) | 4 | 1 | 3 | 3 | 33–36 (2x), 44, 52–59 (1x) |
| Q1HVD8 | gp150 (BDLF3) | Deletion enhances infection of epithelial cells (141) | 6 | 2 | 1 | 6 | 62–71 (4x), 163, 164 |
| Q1HVC5 | gp78 (BILF2) | Unknown | 6 | 4 | 4 | 6 | 154–164 (2x), 165, 183, 187, 192 |
| P68343 | gp350 | Binding (80) | 19 | 18 | 4 | 19 | 249–253 (1x), 746, 750, 752, 753, 754, 774, 775, 776, 779, 780, 786, 787, 788, 791, 802, 803, 804, 805 |
| Q1HVG2 | gp42 | B-cell tropism factor (76, 106) | 1 | 1 | 1 | 0 | 43 |
a Uniprot IDs of reference EBV strain (AG876) are provided.
b Sites mapping to secreted proteins/protein regions facing the lumenal part of the secretory pathway are listed (see all identified glycopeptides in supplemental Data Set S1).