TABLE 1.

Glucagon and epinephrine stimulate hepatic glucose production similarly

Group	Glucose	Insulin	Glucagon	Epinephrine
	mm	pm	pm	pm
Control	7.1 ± 0.2	151 ± 28	165 ± 26	1.7 ± 0.4
Control + ME inhibitor	7.1 ± 0.4	178 ± 42	167 ± 20	1.8 ± 1.0
Glucagon	12.9 ± 1.3**	423 ± 86*	934 ± 222**	2.0 ± 1.1
Glucagon + ME inhibitor	14.2 ± 1.1***	529 ± 79**	1012 ± 54****	2.9 ± 0.9
Epinephrine	15.5 ± 1.8***	421 ± 51*	262 ± 57§§	8.6 ± 1.1***§§§
Epinephrine + ME inhibitor	13.5 ± 1.0***	461 ± 58*	160 ± 14§§§§	10.9 ± 1.1§§§

*, p < 0.05;

**, p < 0.01;

***, p < 0.001;

****, p < 0.0001 versus control;

§§, p < 0.01;

§§§, p < 0.001;

§§§§, p < 0.001 versus glucagon. Data are means ± S.E. of n = 6 per group.