TABLE 3.
List of proteins differentially expressed in endolysosome fractions of 7.5-TLR3 cells following HCV infection
Note: Proteins marked by asterisks in spots 11 and 12 were likely degradation/cleavage products from their full-length counterparts based on their known molecular mass.
| Spot no. | Accession no. | Protein name (gene name) |
|---|---|---|
| Up-regulated | ||
| 1 | P14625 | 94-kDa glucose-regulated protein (GRP94/HSP90B1/gp96) |
| 2 | P13639 | Elongation factor2 (EEF2/EF2) |
| 3 | P11021 | 78-kDa glucose-regulated protein (GRP78/HSPA5/BiP) |
| 4 | P10809 | 60-kDa heat shock protein, mitochondrial(HSP60/HSPD1) |
| 5 | P04040 | Catalase (CAT) |
| 6 | P00367 | Glutamate dehydrogenase 1, mitochondrial (GDH1/GLUD1) |
| 7 | P06733 | α-Enolase (ENO1) |
| 8 | P07954 | Fumarate hydratase, mitochondrial (FH) |
| 9 | P22234 | Multifunctional protein ADE2 (ADE2/PAICS) |
| 10 | unknown | Unknown |
| 11 | Q8IZQ1 | WD repeat and FYVE domain-containing protein3(WDFY3/ALFY)* |
| Q9GZT8 | NIF3-like protein1 (NIF3L1/ALS2CR1) | |
| Q15417 | Calponin-3 (CNN3) | |
| 12 | O00754 | Lysosomal α-mannosidase (LAMAN/MAN2B1)* |
| P13716 | δ-Aminolevulinic acid dehydratase (ALAD/ALADH) | |
| 13 | P00338 | l-Lactate dehydrogenase A chain (LDHA/LDH1) |
| Down-regulated | ||
| 14 | Q9Y265 | RuvB-like1 (RUVBL1/TIP49) |
| 15 | P15104 | Glutamine synthetase (GLUL/GLNS) |
| 16 | O75821 | Eukaryotic translation initiation factor 3 subunitG(EIF3G/EIF3S4) |