Schematic overview of zebrafish definitive hematopoiesis. Green arrow lines indicate the myeloid lineage and blue arrow lines indicate the lymphoid lineage. Transcription factors implicated in hematopoiesis are shown next to each cell type and those associated with mutations, chromosomal abnormalities, or misexpression in leukemia are shown in red. HSC hematopoietic stem cells, CMP common myeloid progenitor, CLP common lymphoid progenitor, GMP granulo/cyte/macrophage progenitors, TEP thrombocyte and erythroid progenitor, Pro-B pro-B-lymphocytes, Pro-T pro-T-lymphocytes