. Author manuscript; available in PMC: 2017 Feb 15.

Published in final edited form as: Chem Res Toxicol. 2016 Jan 21;29(2):162–168. doi: 10.1021/acs.chemrestox.5b00371

Table 2.

New and Distinctive Exposures in Mainstream Smoke from Little Cigars

	estimated detection limit (μg/rod)	estimated concentration^a (μg/rod)		estimated concentration^a (μg/(g TPM))
	estimated detection limit (μg/rod)	little cigars	cigarettes	little cigars	cigarettes
ambrox	0.2	0.4 (0.1)	ND	17 (4)	ND
CASRN 100679-85-4
C₁₆H₂₈O
new exposure
3-methylbutanenitrile	0.6	0.7 (0.4)	ND^b	30 (20)	ND^b
CASRN 625-28-5
C₅H₉N
distinctive exposure
4-methylimidazole	NM	12^c (4)	3 (1)	500^c (100)	180 (40)
CASRN 822-36-6
C₄H₆N₂
distinctive exposure

ND = not detected. NM = not measured.

Mean values, with standard deviations indicated in parentheses, determined from spiked samples.

Compound has been reported as a smoke constituent with concentrations ≤0.2 μg/rod for some cigarette products not tested in the present study.³⁰

Significantly greater (95% confidence level) than result for cigarettes.