Fig 1. B. bronchiseptica LapA domain organization.

Diagram showing the organization of the lapD, lapG and brtA genes in B. bronchiseptica (top) as well as the domain organization of the BrtA protein (bottom). The narrow arrows indicate the location of the primers used in the RT-PCR experiment. The thick, black arrow indicates the specific cleavage site for LapG. The type I secretion signal (T1SS) and T1SS target domains of BrtA are also shown (orange and cyan, respectively), as is the von Willebrand Factor A (vWFA) domain (light green). The repeat regions are indicated by the 8 yellow barrels. Domains found in repeated regions are also indicated: CADG domain (blue), VCBS domain (green) and IDR (interdomain region, red and yellow). The CADG and VCBS domain names are based on core conserved amino acid.