Table 1. Baseline characteristics of the patients with alcoholic hepatitis and healthy controls.
| Alcoholic hepatitis patients | Healthy controls | |
|---|---|---|
| Gender: F/M | 3/17 | 2/5 |
| Age (years) (mean±SD) | 51±6 | 50±8 |
| Weight (kg) (mean±SD) | 85.4±19.0 | 82.3±16.8 |
| Height (cm) (mean±SD) | 176±8 | 179±6 |
| Body mass index (kg/m2) (median (IQR)) | 26.0 (6.7) | 24.0 (6.0) |
| Ascites (yes/no) | 11/9 | 0/7** |
| Hepatic encephalopathy (yes/no) | 4/16 | 0/7 |
| Aspartate aminotransferase (U/L) (mean±SD) | 120±31 | 32±15* |
| Alanine aminotransferase (U/L) (median (IQR)) | 55 (45) | 23 (16)* |
| Aspartate aminotransferase/alanine aminotransferase ratio (mean±SD) | 2.3±0.6 | 1.2±0.4* |
| Bilirubin (μmol/L) (mean±SD) | 282±155 | 9±2* |
| Alkaline phosphatase (U/L) (median (IQR)) | 213 (162) | 56 (14)* |
| Albumin (g/L) (mean±SD) | 21±4 | 37±1* |
| International normalized ratio (mean±SD) | 1.8±0.6 | 1.1±0.1* |
| Coagulation factors II, VII, X (median (IQR)) | 0.33 (0.41) | 0.91 (0.23)* |
| Platelet count (x109/L) (mean±SD) | 180±92 | 240±59 |
| Hemoglobin (mmol/L) (mean±SD) | 6.5±1.2 | 8.6±0.7* |
| Sodium (mmol/L) (mean±SD) | 130±7 | 139±2* |
| Urea (mmol/L) (median (IQR)) | 3.7 (3.3) | 4.5 (2.5) |
| Creatinine (μmol/L) (median (IQR)) | 62 (36) | 78 (10) |
| C-reactive protein (mg/L) (mean±SD) | 31.4±20.7 | 0.6±0.0* |
| White blood cell count (x109/L) (mean±SD) | 13.5±5.6 | 5.0±0.9* |
| Neutrophils (x109/L) | 9.5±4.6 | 2.6±0.9* |
| Soluble CD163 (mg/L) (mean±SD) | 19.4±6.6 | 1.6±0.3* |
| Interleukin-6 (ng/L) (median (IQR)) | 25.4 (44.4) | NA |
| Tumor necrosis factor α (ng/L) (median (IQR)) | 2.8 (1.5) | NA |
* P<0.01 compared with alcoholic hepatitis patients.
** P<0.05 compared with alcoholic hepatitis patients.
NA = not applicable; IQR = interquartile range.