Table 1.
Baseline Characteristics of Patients with Crohn’s Disease according to the C-Reactive Protein Level at Diagnosis
| Variable | CRP >20 (n=373) | CRP ≤20 (n=332) | p-value |
|---|---|---|---|
| Age, yr | 25.4±10.1 | 28.6±14.2 | <0.001 |
| Sex, male/female | 285/88 | 238/94 | 0.153 |
| Time to follow-up, mo | 86.4±44.1 | 83.5±43.9 | 0.379 |
| BMI, kg/m2 | 19.1±3.3 | 20.9±4.2 | <0.001 |
| Smoking status | 0.020 | ||
| Never smoker | 245 (77.8) | 168 (70.0) | |
| Current smoker | 46 (14.6) | 36 (15.0) | |
| Ex-smoker | 16 (5.1) | 31 (12.9) | |
| Stop smoking after treatment | 8 (2.5) | 5 (2.1) | |
| Family history of IBD | 9 (2.4) | 7 (2.1) | 0.447 |
| Hb, g/dL | 11.9±1.9 | 12.8±2.1 | <0.001 |
| Hct, % | 36.0 | 38.1 | <0.001 |
| ESR, mm/hr | 47.5±29.2 | 23.6±21.5 | <0.001 |
| CDAI at diagnosis | 217.5±110.2 | 164.6±89.2 | <0.001 |
| Location at diagnosis* | <0.001 | ||
| L1 (ileal) | 51 (17.5) | 91 (32.9) | |
| L2 (colonic) | 71 (24.4) | 48 (17.3) | |
| L3 (ileocolonic) | 164 (56.4) | 134 (48.4) | |
| L4 (upper GI) | 5 (1.7) | 4 (1.4) | |
| Behavior at diagnosis* | 0.503 | ||
| B1 (inflammatory) | 176 (71.3) | 193 (72.6) | |
| B2 (stricturing) | 32 (13.0) | 39 (14.7) | |
| B3 (penetrating) | 39 (15.8) | 34 (12.8) | |
| Steroid use at diagnosis | 154 (41.2) | 84 (25.3) | <0.001 |
| History of anti-TB medication | 67 (18.0) | 70 (21.1) | 0.296 |
| History of perianal disease | 108 (29.0) | 81 (24.4) | 0.173 |
Data are presented as mean±SD or number (%).
CRP, C-reactive protein; BMI, body mass index; IBD, inflammatory bowel disease; Hb, hemoglobin; Hct, hematocrit; ESR, erythrocyte sedimentation rate; CDAI, Crohn’s disease activity index; GI, gastrointestinal; TB, tuberculosis.
*
Location and behavior at the time of diagnosis were unavailable in 137 and 192 patients, respectively.