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. 2016 Jun 30;21(2):95–103. doi: 10.15430/JCP.2016.21.2.95

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Copyright © 2016 Korean Society of Cancer Prevention

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Effects of normal diet (ND) and high-fat diet (HFD) on intestinal permeability and colonic tight junction (TJ) protein levels in APC^min/+ mice. APC^min/+ mice were fed either ND or HFD for 12 weeks. (A) Intestinal permeability was assessed by measuring blood fluorescein isothiocyanate (FITC)-dextran level after gavage FITC-dextran (600 mg/kg body weight). Colonic expressions of tight junction proteins, (B) occludin, (C) claudin-1, and (D) zonula occludens-1 (ZO-1), were evaluated by Western blotting. Graph shows ratios of the intensities of TJ protein bands normalized with that of β-actin band. Values are expressed as mean ± SD (n = 10). *Significant (P < 0.05).