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. 2016 Feb 24;18(8):1120–1128. doi: 10.1093/neuonc/now023

Fig. 5.

Fig. 5.

Antitumor efficacy of local delivery of FGK45 in the bRiTs-G3 model. The mechanism underlying antitumor efficacy of local delivery of FGK45 was evaluated in the bRiTs-G3 model. Two days after treatment, TUNEL staining revealed an increased number of apoptotic cells in the FGK45-treated group. TUNEL (red) staining in the bRiTs-G3 model, counterstained with DAPI (blue). Scale bars, 100 µm. The number of cells was counted under ×400 magnification. Bars indicate mean ± SD (***P < .05). Immunohistochemistry for mouse CD4 and CD8-positive T cells (red) in the bRiTs-G3 model was performed using brains harvested 7 days after treatment. Nuclei were counterstained with DAPI (blue). The number of cells positively stained for CD4 or CD8 was counted under ×400 magnification. Bars indicate mean ± SD (***P < .05). Scale bars, 50 µm.