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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Expert Opin Drug Deliv. 2016 Apr 4;13(6):873–889. doi: 10.1517/17425247.2016.1167035

Figure 4.

Figure 4

Images of tumor-bearing animals infused with liposomes and treated with an external physical stimulus to increase tumor accumulation. Gamma camera images of sarcoma-bearing cat acquired 3.5 h after 99mTc-PEG-liposomes and before (A) or after (B) ultrasound generated hyperthermia. Reproduced with permission from [69]. Transverse MR image of mouse with subcutaneously implanted tumors in each flank. A magnet was glued to skin over left tumor for 24 h after intravenous injection of pegylated magnetoliposomes. The magnet was removed before imaging. The magnetically targeted tumor (Arrow) appears darker than contralateral control tumor indicating preferential accumulation of magnetoliposomes. Reproduced with permission from [82]. Gamma camera images of rats bearing prostate tumors implanted in the thigh and receiving no (D) or 500 cGy (E) of ionizing radiation directed at the tumor. Images were acquired 20 h after intravenous injection of 99mTc-PEG-liposomes. The ionizing radiation was delivered 24 h before injection of the 99mTc-PEG-liposomes. Reproduced with permission from [69]. Sagittal SPECT/CT images of tumor-bearing rats intravenously injected with 99mTc-liposomal doxorubicin and without (F) or with (G) radiofrequency ablation.