Figure 11.

Predicted maximum bubble diameter (D_MAX) for a 5 nm nucleus exposed to a single cycle microtripsy pulse (a) and a 20 nm nucleus exposed to a single cycle shock scattering histotripsy pulse (b). For each insonation type, the maximum bubble size is independent of the initial nuclei size for nuclei larger than the limiting size (5 nm for microtripsy and 20 nm for shock scattering histotripsy). Note that growth of the nuclei will only occur for pressures greater than the Blake threshold (Holland and Apfel 1989). Note also the peak rarefactional pressure range is difference for nuclei exposed to microtripsy pulses (a) and histotripsy pulses (b).