Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jun 7;36(2):676–684. doi: 10.3892/or.2016.4860

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

FLT enhances the antitumoral effect of TMZ by activating CHOP. (A) Effect of TMZ on the proliferation of C6 cells. (B) Cytotoxicity analysis of TMZ-induced growth suppression with or without FLT co-treatment in the C6 cells. (C) Synergistic analysis is presented with Fa-CI plot. (D) Combination indices for TMZ and FLT combination therapy, as computed by CompuSyn. (E) Caspase-3 activity analysis following TMZ and FLT in the C6 cells. (F) CHOP knockdown attenuated the synergistic effect of FLT on proliferative inhibition of C6 cells induced by a 24-h treatment of TMZ. The data are presented as means ± SEM from at least three independent experiments (^*P<0.05, ^**P<0.01). FLT, fluoxetine; TMZ, temozolomide.