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. 2016 Jun 2;36(2):685–695. doi: 10.3892/or.2016.4849

Figure 1.

Figure 1

Effect of the HER-2 gene on the expression of HER-2 in IOMM-Lee cells. (A) The levels of HER-2 in different cell lines. Compared with NC-sh, the levels of HER-2 in the IOMM-Lee cell lines transfected with HER2-sh1, HER2-sh2, HER2-sh3 were decreased, obviously HER2-sh2 (**P<0.01). (B) The mRNA levels of HER-2 in the IOMM-Lee malignant meningioma cells. Compared with the NC-overexpression, the expression of HER-2 in the IOMM-Lee cells transfected with HER-2-over was significantly increased (**P<0.01). (C and D) The protein expression of HER-2 in IOMM-Lee cells transfected with HER-2-sh and HER-2-over were analyzed by western blotting. (C) The protein expression levels of HER-2 in the IOMM-Lee cell lines transfected with HER-2-sh2 obviously decreased (**P<0.01). The data are expressed as the mean standard deviation from three independent experiments. (D) The protein expression levels of HER-2 in the IOMM-Lee cell lines transfected with HER-2-over obviously increased (**P<0.01). The data are expressed as the mean standard deviation from three independent experiments. Blank, blank control; NC, negative; sh, short hairpin, over, overexpression.