Figure 1.

Bevacizumab shows antitumor activity in the early phase but not in the late phase in HT-29 xenograft model. Mice were randomized into 2 groups (n=5–10/group). Bevacizumab and control human IgG were intraperitoneally administered once a week. Data points show mean ± SD of tumor volume. Control, open circles; bevacizumab, closed circles. ^aP<0.05 versus control IgG group by Wilcoxon test.