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. 2016 Jun 29;11:867–872. doi: 10.2147/CIA.S107037

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© 2016 Luo and Chen. This work is published and licensed by Dove Medical Press Limited

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Dysregulated lncRNAs in AD.

Notes: BACE1-AS, 17A, 51A, and NDM29 directly or indirectly increase Aβ formation and/or the Aβx-42/Aβx-40 ratio. BC200 modulates local protein synthesis to maintain long-term synaptic plasticity. NAT-Rad18 is implicated in apoptosis. The arrows next to Aβ indicates up/down expression.

Abbreviations: Aβ, amyloid β peptide; AD, Alzheimer’s disease; BACE1, β-site APP cleaving enzyme-1; BC200, brain cytoplasmic 200 RNA; eIF4A, eukaryotic initiation factor 4A; lncRNAs, long noncoding RNAs; NDM29, neuroblastoma differentiation marker 29; SORL1, sortilin-related receptor gene; mRNA, messenger RNA.