Table 2.
Comparative studies: study and patient characteristics (all trauma except for Badjie et al. (2013))
| Authors | Study type paper/abstract (timing context) | Purpose of study | Group (secondary transfers) | Patients in study arm (% male) | Age | Mechanism of injury | Injury Burden | Intervention |
| Price et al. (49) Portland, OR | Matched cohort | Compare efficacy of early blood transfusion | Non-recipients (Unknown) | 162 | Unknown | Unknown | Unknown | |
| abstract (retrospective civilian) | PHBP recipients (unknown) | 84 | Unknown | Unknown | Unknown | PRBC: 426 ml | ||
| Sumida et al. (48) Chattanooga, TN, Hartford, CN | Cohort full text (retrospective civilian) | Analyze the effect of PHBP on physiologic parameters and outcomes | Non-recipients (unknown) | 31 (Unknown) | 30.4 | Unknown | ISS: 27.8 | |
| RTS: 7.0 | ||||||||
| TRISS: 0.669 | ||||||||
| PHBP recipients (unknown) | 17 (Unknown) | 31.2 | Unknown | ISS: 28.0 | “blood”: 711 mL | |||
| RTS: 6.3 | ||||||||
| TRISS: 0.524 | ||||||||
| Kim et al. (37) Rochester, MN | Cohort full text (retrospective civilian) | Will delivery of prehospital plasma improve coagulopathy | PRBC only (Transfers: 54%) | 50 (60%) | 41 | Penetrating: 9 (18%) | ISS: 23 | PRBC: 1u |
| TRISS: 0.66 | ||||||||
| PRBC + Plasma (transfers: 100%) | 9 (100%) | 54 | Penetrating: 3 (33%) | ISS: 27 | PRBC: 2.5u | |||
| TRISS: 0.24* | Plasma: 2.1u | |||||||
| Badjie et al. (39) Rochester, MN | Cohort abstract (retrospective civilian) | To evaluate mortality rates of patients who received a 1:1 FFP: RBC ratio en-route | PRBC: plasma 2:1 (unknown) | 79 (Unknown) | Unknown but “comparable” | Reasons for transport not stated but “comparable” | Unknown | Up to 2u PRBC + 2u Plasma + 2u |
| PRBC OR 2u Plasma + 4u PRBC | ||||||||
| PRBC: Plasma 1:1 (unknown) | 79 (Unknown) | Unknown | Up to 3u plasma + 3u PRBC | |||||
| PHBP recipients (transfers: 0%) | 66 (61%) | Median 40 | Unknown | Not specified | ||||
| Brown et al. (35-i) Pittsburgh, PA | Cohort | Is pretrauma center RBC transfusion associated with reduced mortality and early TIC? | Non-recipients (transfers: 4%) | 1365 (67%) | 41 (26–54) | Unknown | ISS: 33 (22–41) | |
| full text (retrospective civilian) | PHBP recipients (transfers: 48%) | 50 (64%) | 41 (28–52) | Unknown | ISS: 37 (24–43) | PRBC: 1.3u (1.0–2.3) | ||
| Brown et al. (35-ii) Pittsburgh, PA | Matched cohort full text (retrospective civilian) | Is pretrauma center RBC transfusion associated with reduced mortality and TIC in a matched cohort? | Non-recipients (transfers: 24%) | 78 (72%) | 37 (24–55) | Unknown | ISS: 30 (23–43) | |
| PHBP recipients (transfers: 29%) | 35 (60%) | 36 (28–52) | Unknown | ISS: 34 (18–43) | PRBC: 1.2u (1.0–2.0) | |||
| Brown et al. (36-i) Pittsburgh, PA | Cohort full text (retrospective civilian) | Is pretrauma center RBC transfusion associated with reduced 24-h mortality, TIC, shock and Tx requirements in air medical transport | Non-recipients (transfers: 75%) | 480 (67%) | 49 (31–68) | Blunt: 395 (82%) Penetrating: 85 (18%) | ISS: 17 (9–27) | |
| PHBP recipients (transfers: 68%) | 240 (69%) | 49 (28–71.5) | Blunt: 191 (80%) Penetrating: 49 (20%) | ISS: 18 (10–29) | PRBC: 300 mL (IQR: 200–500) | |||
| Brown et al. (36-ii) Pittsburgh, PA | Cohort full text (retrospective civilian) | Is pretrauma center RBC transfusion associated with reduced 24-h mortality, TIC, shock and Tx requirements in patients transported from scene | Non-recipients (transfers: 0%) | 142 (68%) | 37 (25–65) | Blunt: 98 (69%) | ISS: 22 (13–29) | |
| PHBP recipients (transfers: 0%) | 71 (83%) | 42 (24–55) | Penetrating: 44 (31%) | ISS: 22 (10–34) | PRBC: 300 mL | |||
| Blunt: 98 (69%) | (IQR: 200–500) | |||||||
| Penetrating: 44 (31%) | ||||||||
| Wheeler et al. (57) Lebanon, NH | Case-control Full Text (Retrospective Civilian) | Identify factors associated with hypothermia | Non-hypothermic (transfers: 0%) | 647 (68%) | 39 (SD: 19) | Unknown | ISS: 16 (SD: 11) | PRBC given to 3% of subjects |
| RTS: 7.34 (SD: 1.19) | ||||||||
| TRISS: 0.93 (SD: 0.16) | ||||||||
| Hypothermic (<35°C) (Transfers: 0%) | 60 (68%) | 41 (SD: 20) | Unknown | ISS: 26 (SD: 12) | Up to 3u PRBC given to 17% of subjects | |||
| RTS: 5.86 (SD: 1.85) | ||||||||
| TRISS: 0.75 (SD: 0.29) | ||||||||
| O’Reilly et al. (40) Afghanistan | Matched cohort full text (retrospective military) | “PHBP will be associated with reduction in mortality” | Non-recipients | 97 (100%) | 23 (21–28) | Explosive: 48 (49%) | mISS: 16 (9–25) | |
| GSW: 46 (47%) | mNISS: 21 (14–34) | |||||||
| Blunt: 3 (3%) | ||||||||
| PHBP recipients | 97 (98%) | 24 (20–28) | Explosive: 50 (52%) | mISS: 16 (9–25) | PRBC: 1u (IQR: 1–2) | |||
| GSW: 46 (47%) | mNISS: 22 (15–33) | [R: 0–4] | ||||||
| Blunt: 1 (1%) | Plasma: 2u (IQR: 1–2) | |||||||
| [R: 0–4] | ||||||||
| Smith et al. (46) Afghanistan | Cohort abstract (full data available) (retrospective military) | Is PHBP receipt associated with reduced mortality or coagulopathy? | Non-recipients | 775 (96.6%) | Median band: 17–24 | Explosive: 423 (55%) | mISS: 18 (14–26) | |
| GSW: 274 (35%) | mNISS: 25 (18–34) | |||||||
| MVC: 46 (6%) | ||||||||
| Burn: 11 (1%) | ||||||||
| Other: 21 (3%) | ||||||||
| PHBP recipients | 272 (98.5%) | Median band: 17–24 | Explosive: 250 (92%) | mISS: 26 (18–30) | PRBC: 2u (IQR: 1–2) | |||
| GSW: 19 (7%) | mNISS: 41 (29–54) | [R: 0–4] | ||||||
| MVC: 3 (1%) | Plasma: 2u (IQR: 1–2) | |||||||
| [R: 0–4] | ||||||||
| Gross et al. (56) Afghanistan | Conference poster (retrospective military) | Not stated | Non-recipients | 54 (Unknown) | 25 (22–28) | Unknown | Unknown | |
| PHBP recipients | 66 (Unknown) | 25 (24–29) | Unknown | Unknown | not specified |
mISS and mNISS indicates ISS and NISS derived from the military edition of the Abbreviated Injury Scale (2005).